The goal of mechanobiology is to understand the functional effects of the structural micro-environment and force-induced deformations. These factors, when combined with chemical signals, determine the local cell response that is integrated to drive multicellular functions in whole organisms.
This resource deals with the process of mechanotransduction, starting with the detection of a mechanical stimulus and ending with an appropriate cellular response being mounted. This pathway is in fact cyclical, with the cellular response resulting in further testing of the environment, so creating a feedback loop. This process involves multiple cellular events at both a genetic and molecular level, which shall be discussed.
Each topic is written in a pyramid structure. The top of the pyramid is represented by an overview page, providing a basic description of a given function or process. These pages target a broad spectrum of readers and assume only a basic understanding of biology. Further down the pyramid, the reader will encounter the steps involved in the process described and functional modules that address specific mechanical aspects. These pages outline the protein complexes involved and the mechanisms by which they achieve the given process or function. These pages assume the readers have a more in-depth knowledge of scientific terms and principles.
Please reference the work as detailed in Citing MBInfo. Images may not to be reproduced without prior consent.
For further information please contact us at feedback@mechanobio.info.
MBInfo © 2012 National University of Singapore.
What is MBInfo?
MBInfo is a unique, multipurpose information resource, created at the Mechanobiology Institute, Singapore. MBInfo provides in-depth reviews on the mechanics of cellular and molecular function. Through its wiki-based design, reviews are updated regularly to keep pace with progress within the field. Each review is written by scientists and subsequently peer reviewed by experts in the field to ensure the content is accurate, reliable and up to date. Each review emphasizes the functional and mechanical aspects of a process, rather than the genetic aspects, with the aim of making this resource accessible to a wider audience.Who is MBInfo for?
MBInfo is an ideal resource for scientists working in alternative fields, individuals working in industries where products are based on biological principles or students seeking a reliable introduction to a given cellular process.How can it be used?
For every topic, a series of graphics and/or animations are available. These supplement the reviews, clarify information and guide the reader through complex processes pictorially. This makes MBInfo an ideal teaching resource, whether in the classroom or for clients trying to understand your product. All images and text are copyright protected and are for personal use only.Please reference the work as detailed in Citing MBInfo. Images may not to be reproduced without prior consent.
For further information please contact us at feedback@mechanobio.info.
How can I contribute?
Suggestions and contributions from users are very important to the success of this resource. We invite all interested persons to contribute your information directly to the MBInfo. If you are interested in becoming an MBInfo contributor, please contact us at feedback@mechanobio.info.MBInfo © 2012 National University of Singapore.