At the heart of mechanobiology is the relationship between a cell and its environment. Cells sense and respond to the physical properties of their environment and this is dependent on dynamic subcellular systems that can generate and transduce mechanical force. Downstream integration of these signals into biochemical and genomic pathways cause observable and measurable effects on cell life.
MBInfo provides you with fundamental information on topics relevant to the field of Mechanobiology, and keeps you up-to-date on the latest findings coming out of the Mechanobiology Institute, National University of Singapore.
Together with collaborators around the world, researchers at the Mechanobiology Institute, National University of Singapore, are working to understand how biological systems generate and sense mechanical signals, and establish how each system integrates these mecahnical cues into the biochemcial and genomic pathways that drive cell, tissue, and organ function.
Our researchers are asking many important questions. How do stretchable proteins transduce mechanical force at cell adhesion sites? How is nuclear architecture determined by forces converging on the nucleus, and how does this impact gene transcription in various disease states? How does the mechanical environment influence embryo development and pattern formation? Can mechanical cues be exploited in the next generation of tissue engineering technologies?
The answers to these questions impact the work of researchers across multiple disciplines, and present new ways to consider cell and molecular biology, physiology, developmental biology, pathogenesis and disease progression.
To stay on top of the many scientific discoveries coming from the Mechanobiology Institute, Singapore, and through our collaborations with biophysics and mechanobiology labs worldwide, we present the most recent and impactful findings here on MBInfo.