What are tandem-monomer-binding nucleators 2018-02-05T16:56:09+00:00

What are tandem-monomer-binding nucleators?

Although the most commonly described nucleators are the Arp2/3 complex, and the formins, a third group, known as ‘tandem-monomer-binding nucleators’, has also been identified. Each member possesses tandem repeats of G-actin binding motifs.

Included in this group of nucleators are the Spire proteins, Cordon-bleu (Cobl), Leiomodin (Lmod-2), JMY and adenomatous polyposis coli (APC). Common to each of these proteins are repeats of the actin binding motif Wiskott-Aldrich Syndrome protein (WASp) homology 2 (WH2) domain. However, additional actin binding motifs may be present in the individual members, providing variation not their mechanisms of nucleation, but importantly, in the cellular functions they facilitate.

Video. Spire mediated Actin Filament Nucleation: Read more about actin nucleation: http://www.mechanobio.info/Home/topics/Mechanobiology/What-is-the-Role-of-Actin-Filaments-in-Mechanotransduction/actin-filament-treadmilling Source: Janet Iwasa

Animation used by permission. Source: Janet Iwasa

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