Clathrin-mediated endocytosis (CME) occurs as periodic traveling waves, being co-ordinated spatially and temporally through the nucleation of actin waves. The link between endocytosis and generation of cortical actin waves may provide deeper insight into how cells maintain the composition and dynamics of the plasma membrane
These findings were published in Developmental Cell in 2017.
Yang Y, Ding X, Pipathsouk A, Weiner OD, Wu M. (2017) Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. 43(4):507-521.e4. doi: 10.1016/j.devcel.2017.10.028
More information on the Wu Lab
Figure: The top left of the figure depicts a cell with clathrin-mediated endocytic waves. The top right depics a cross section of the cell with clathrin assembly in process through collective dynamics. Onset of clathrin waves require intermediate levels of PIP3 (red) as well as feedback from downstream components of cortical wave machinery such as FBP17 (green). The arrow represents direction of propagation of clathrin waves.