How do the mechanical properties of cells change with respect to substrate rigidity?

2018-02-19T11:09:32+08:30

How do the mechanical properties of cells change with respect to substrate rigidity?

As stiffness of the extracellular matrix increases, the mechanical properties of the actin cytoskeleton shifts from fluid to solid.

These findings were published in Nature Communications in 2015.

Gupta M, Sarangi BR, Deschamps J, Nematbakhsh Y, Callan-Jones A, Margadant F, Mège RM, Lim […]

What is the role of plastin in C. elegans embryogenesis?

2018-02-08T13:15:06+08:30

What is the role of plastin in C elegans embryogenesis?

Plastin, an actin cross-linking protein, has been shown to be instrumental for efficient cytokinesis and polarization in C. elegans zygotes. By increasing connectivity within the cortical actomyosin network, plastin provides strength to the network, to enable a coordinated cortical flow required to segregate proteins during zygote polarization. Similarly, […]