How do forces affect actin remodeling at distant locations in a cell?

2018-05-31T14:00:32+00:00

How do forces affect actin remodeling at distant locations in a cell?

Forces applied at the periphery of a cell causes actin remodeling around the nucleus, leading to the formation of a transient perinuclear actin rim. The formation of this actin structure is dependent on the force-induced release of Ca2+ ions in the cytoplasm, […]

What role do formins play in epithelial junctional stability?

2018-02-05T14:55:24+00:00

What role do formins play in epithelial junctional stability?

This study addresses the role of formins at epithelial junctions. A major formin, mDia1, is shown to be recruited to Adherens Junctions (AJs) by E-Cadherin and RhoA.  This leads to the organization of actomyosin filaments around the AJs which causes an increase in junctional contractility. […]