How do forces affect actin remodeling at distant locations in a cell?

2018-05-31T14:00:32+00:00

How do forces affect actin remodeling at distant locations in a cell?

Forces applied at the periphery of a cell causes actin remodeling around the nucleus, leading to the formation of a transient perinuclear actin rim. The formation of this actin structure is dependent on the force-induced release of Ca2+ ions in the cytoplasm, […]

How do nuclear phosphoinositides mediate DNA damage repair?

2018-03-01T14:51:15+00:00

How do nuclear phosphoinositides mediate DNA damage repair?

Nuclear phosphoinositides, specifically PIP2 and PIP3, play essential roles in mediating the recruitment of the ATR-ATRIP-pChk signaling axis to sites of DNA repair.

These findings were published in Nature Communications in 2017.

Wang YH et al. DNA damage causes rapid accumulation of phosphoinositides for ATR signaling. Nature Communications. […]

How does Clathrin-Mediated Endocytosis (CME) become synchronized?

2018-02-08T09:54:25+00:00

How does Clathrin-Mediated Endocytosis (CME) become synchronized?

Clathrin-mediated endocytosis (CME) occurs as periodic traveling waves, being co-ordinated spatially and temporally through the nucleation of actin waves. The link between endocytosis and generation of cortical actin waves may provide deeper insight into how cells maintain the composition and dynamics of the plasma membrane

These findings were […]

How do the mechanical properties of cells change with respect to substrate rigidity?

2018-02-19T11:09:32+00:00

How do the mechanical properties of cells change with respect to substrate rigidity?

As stiffness of the extracellular matrix increases, the mechanical properties of the actin cytoskeleton shifts from fluid to solid.

These findings were published in Nature Communications in 2015.

Gupta M, Sarangi BR, Deschamps J, Nematbakhsh Y, Callan-Jones A, Margadant F, Mège RM, Lim […]

What role do formins play in epithelial junctional stability?

2018-02-05T14:55:24+00:00

What role do formins play in epithelial junctional stability?

This study addresses the role of formins at epithelial junctions. A major formin, mDia1, is shown to be recruited to Adherens Junctions (AJs) by E-Cadherin and RhoA.  This leads to the organization of actomyosin filaments around the AJs which causes an increase in junctional contractility. […]

What is the role of DAAM1 at actin nodes?

2018-01-29T15:40:12+00:00

What is the role of DAAM1 at actin nodes?

When actin filaments are depolymerized by latrunculin A, DAAM1 becomes free to move, and it associates with the newly formed actin nodes and stabilizes them. At these nodes, DAAM1 organizes short actin filaments, providing the foundation for the regrowth of actin filaments and stress fiber

These […]