How do forces affect actin remodeling at distant locations in a cell?

2018-05-31T14:00:32+00:00

How do forces affect actin remodeling at distant locations in a cell?

Forces applied at the periphery of a cell causes actin remodeling around the nucleus, leading to the formation of a transient perinuclear actin rim. The formation of this actin structure is dependent on the force-induced release of Ca2+ ions in the cytoplasm, […]

How do the mechanical properties of cells change with respect to substrate rigidity?

2018-02-19T11:09:32+00:00

How do the mechanical properties of cells change with respect to substrate rigidity?

As stiffness of the extracellular matrix increases, the mechanical properties of the actin cytoskeleton shifts from fluid to solid.

These findings were published in Nature Communications in 2015.

Gupta M, Sarangi BR, Deschamps J, Nematbakhsh Y, Callan-Jones A, Margadant F, Mège RM, Lim […]