How are apoptotic cells removed from the epithelial tissue in Drosophila pupae?

2018-04-16T14:41:11+00:00

How are apoptotic cells removed from the epithelial tissue in Drosophila pupae?

In Drosophila pupae, the detachment and expulsion of apoptotic cells from the epithelium is driven by: remodeling of adherens junctions between the apoptotic and neighboring cell surfaces, the contraction of actomyosin structures in both apoptotic and neighboring cells, and the modulation of […]

What is the role of non-junctional E-cadherin clusters?

2018-03-12T12:57:36+00:00

What is the role of non-junctional E-cadherin clusters?

Non-junctional E-cadherin clusters play a non-canonical role in stabilizing the cortex and resisting its flow, in addition to their well-characterized role in mediating cell-cell junctions.

This study was published in Current Biology in 2017.

Padmanabhan A et al. Non-junctional E-cadherin clusters regulate the actomyosin cortex in the C. […]

What role do formins play in epithelial junctional stability?

2018-02-05T14:55:24+00:00

What role do formins play in epithelial junctional stability?

This study addresses the role of formins at epithelial junctions. A major formin, mDia1, is shown to be recruited to Adherens Junctions (AJs) by E-Cadherin and RhoA.  This leads to the organization of actomyosin filaments around the AJs which causes an increase in junctional contractility. […]