How do H-NS proteins bind bacterial DNA?


How do H-NS proteins bind bacterial DNA?

The binding of H-NS to the bacterial DNA is initiated by electrostatic interactions between the positive residues on the H-NS linker and the negatively charged DNA. The initial contacts established by the linker then promotes engagement by the C-terminal DNA-binding domain of H-NS proteins.

These findings were published […]

Super-resolution imaging of nanoscale chromosome contacts


How can super resolution imaging be used to assess nanoscale chromosome contacts?

This research provides the first direct visualization of functional gene clusters, at a nano-scale level. Functional gene clusters are genes that may be on the same or different chromosomes but are regulated by the same transcriptional factors that enable their intermingling with […]