How does traction force affect the nature of adhesion structures like podosomes?

2018-02-08T13:14:10+08:30

How does traction force affect the nature of adhesion structures like podosomes?

Yu et al showed that podosomes, which are usually formed by either macrophages or transformed cells, can also be formed by normal fibroblasts on fluid matrix devoid of any traction force. This was mediated by the phosphoinositide 3-kinase (PI3K) and PIP3 in […]

What is the role of basolateral cell protrusions in driving Drosophila germ-band extension?

2018-02-19T11:10:53+08:30

What is the role of basolateral cell protrusions in driving Drosophila germ-band extension?

A study published in Nature Cell Biology reveals concerted roles of both apical actomyosin contractions and basolateral actin-based protrusions in facilitating cell intercalation during Drosophila germband extension.

These findings were published in Nature Cell Biology in 2017.

Sun Z, Amourda C, Shagirov M, […]

What is the role of DAAM1 at actin nodes?

2018-01-29T15:40:12+08:30

What is the role of DAAM1 at actin nodes?

When actin filaments are depolymerized by latrunculin A, DAAM1 becomes free to move, and it associates with the newly formed actin nodes and stabilizes them. At these nodes, DAAM1 organizes short actin filaments, providing the foundation for the regrowth of actin filaments and stress fiber

These […]

What is the role of plastin in C. elegans embryogenesis?

2018-02-08T13:15:06+08:30

What is the role of plastin in C elegans embryogenesis?

Plastin, an actin cross-linking protein, has been shown to be instrumental for efficient cytokinesis and polarization in C. elegans zygotes. By increasing connectivity within the cortical actomyosin network, plastin provides strength to the network, to enable a coordinated cortical flow required to segregate proteins during zygote polarization. Similarly, […]