How does Clathrin-Mediated Endocytosis (CME) become synchronized?

2018-02-08T09:54:25+00:00

How does Clathrin-Mediated Endocytosis (CME) become synchronized?

Clathrin-mediated endocytosis (CME) occurs as periodic traveling waves, being co-ordinated spatially and temporally through the nucleation of actin waves. The link between endocytosis and generation of cortical actin waves may provide deeper insight into how cells maintain the composition and dynamics of the plasma membrane

These findings were […]

How do the mechanical properties of cells change with respect to substrate rigidity?

2018-02-19T11:09:32+00:00

How do the mechanical properties of cells change with respect to substrate rigidity?

As stiffness of the extracellular matrix increases, the mechanical properties of the actin cytoskeleton shifts from fluid to solid.

These findings were published in Nature Communications in 2015.

Gupta M, Sarangi BR, Deschamps J, Nematbakhsh Y, Callan-Jones A, Margadant F, Mège RM, Lim […]

What role do formins play in epithelial junctional stability?

2018-02-05T14:55:24+00:00

What role do formins play in epithelial junctional stability?

This study addresses the role of formins at epithelial junctions. A major formin, mDia1, is shown to be recruited to Adherens Junctions (AJs) by E-Cadherin and RhoA.  This leads to the organization of actomyosin filaments around the AJs which causes an increase in junctional contractility. […]