How do nuclear phosphoinositides mediate DNA damage repair?

2018-03-01T14:51:15+00:00

How do nuclear phosphoinositides mediate DNA damage repair?

Nuclear phosphoinositides, specifically PIP2 and PIP3, play essential roles in mediating the recruitment of the ATR-ATRIP-pChk signaling axis to sites of DNA repair.

These findings were published in Nature Communications in 2017.

Wang YH et al. DNA damage causes rapid accumulation of phosphoinositides for ATR signaling. Nature Communications. […]

How does traction force affect the nature of adhesion structures like podosomes?

2018-02-08T13:14:10+00:00

How does traction force affect the nature of adhesion structures like podosomes?

Yu et al showed that podosomes, which are usually formed by either macrophages or transformed cells, can also be formed by normal fibroblasts on fluid matrix devoid of any traction force. This was mediated by the phosphoinositide 3-kinase (PI3K) and PIP3 in […]