How do H-NS proteins bind bacterial DNA?

The binding of H-NS to the bacterial DNA is initiated by electrostatic interactions between the positive residues on the H-NS linker and the negatively charged DNA. The initial contacts established by the linker then promotes engagement by the C-terminal DNA-binding domain of H-NS proteins.

These findings were published […]

What are the similarities and differences in molecular mechanisms underlying the response to acid and osmotic stress in Salmonella and E.coli?

A novel paradigm for the bacterial response to acidic environments in vitro and in a host describes how gram negative bacteria such as Salmonella and E. coli self-acidify for prolonged periods in response to […]

How do Salmonella decide between the virulent lifestyle in macrophages and carrier state in gall bladder biofilms?

The virulent or carrier state of Salmonella is determined by the phosphorylation status of SsrB, a transcriptional regulator protein. While the virulent lifestyle is regulated through phosphorylation of SsrB by the SsrA kinase, the biofilm state is […]