How does talin buffer forces in cells?

2018-06-04T10:17:25+00:00

How does talin buffer forces in cells?

Talin, a well-known mechanosensor, is able to buffer forces through the stochastic folding and unfolding of its various rod domains. By buffering cellular forces, talin defines the physiological force range in which a number of mechanosensitive cellular processes can take place.

These findings were published in Nature Communications […]

How was the binding of multiple vinculins to stretched talin achieved in real-time?

2018-02-20T10:10:20+00:00

How was the binding of multiple vinculins to stretched talin achieved in real-time?

This study shows the dynamic and cooperative binding of multiple vinculins to a stretched antiparallel dimer of talin using super resolution microscopy.

These findings were published in Nano Letters in 2016.

Hu X, Jing C, Xu X, Nakazawa N, Cornish VW, Margadant FM, […]