What role do formins play in epithelial junctional stability?

2018-02-05T14:55:24+08:30

What role do formins play in epithelial junctional stability?

This study addresses the role of formins at epithelial junctions. A major formin, mDia1, is shown to be recruited to Adherens Junctions (AJs) by E-Cadherin and RhoA.  This leads to the organization of actomyosin filaments around the AJs which causes an increase in junctional contractility. […]

What is the role of DAAM1 at actin nodes?

2018-01-29T15:40:12+08:30

What is the role of DAAM1 at actin nodes?

When actin filaments are depolymerized by latrunculin A, DAAM1 becomes free to move, and it associates with the newly formed actin nodes and stabilizes them. At these nodes, DAAM1 organizes short actin filaments, providing the foundation for the regrowth of actin filaments and stress fiber

These […]