Can somatic cells be reprogrammed into pluripotent stem cells using mechanical cues alone?

2018-06-04T17:04:27+00:00

Can somatic cells be reprogrammed into pluripotent stem cells using mechanical cues alone?

It has been shown that mouse fibroblasts efficiently dedifferentiate and express markers of pluripotency after being geometrically confined over 10 days, without exogenous biochemical factors. After 6 days mesenchymal genes are repressed, and after 10 days ESC and iPSC specific genes […]